Tumor-Specific CTL to the Brain Mechanism for Efficient Recruitment of Cutting Edge: Cross-Presentation as a
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Cutting edge: cross-presentation as a mechanism for efficient recruitment of tumor-specific CTL to the brain.
The number and localization of effector cells to the tumor site are crucial elements for immune rejection of solid tumors. However, for cerebral malignancies, antitumor responses need to be finely tuned to avoid neuropathologic consequences. In this study, we determine factors that regulate CTL localization and tumoricidal function after intracerebral implantation of tumors expressing model Ag....
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Heat shock proteins (HSPs) such as Hsp70, gp96, and Hsp90 have been shown to elicit intriguing, efficient CTL responses by cross-presentation via an as yet entirely unknown mechanism. Oxygen-regulated protein 150 (ORP150), also known as grp170, is an endoplasmic reticulum-resident HSP and is up-regulated by hypoxia. It has been demonstrated that ORP150 binds tumor-associated Ag peptides within ...
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Persistent viruses have developed potent strategies to overcome host immune defenses. In particular, viral interference with Ag presentation by HLA class I molecules can effectively impair the host's CTL function. Here we provide evidence for a novel aspect of differential splicing on endogenous processing of a latent viral transcript resulting in dominant protein isoforms from which the CTL de...
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Professional APC play a central role in generating antiviral CD8(+) CTL immunity. However, the fate of such APC following interaction with these same CTL remains poorly understood. We have shown previously that prolonged Ag presentation persists in the presence of a strong CTL response following HSV infection. In this study, we examined the mechanism of survival of APC in vivo when presenting a...
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An instantaneous rigid force model for prediction of cutting forces in ball-end milling of sculptured surfaces is presented in this paper. A commercially available geometric engine is used to represent the cutting edge, cutter and updated part geometries. The cutter used in this work is an insert type ball-end mill. Intersecting an inclined plane with the cutter ball nose generates the cutting...
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تاریخ انتشار 2003